Peristeri  announced on November 11th, in the wake of a home loss to VEF Riga in BCL Week 4 action, that they had agreed mutually with head coach Nikos Papanikolopoulos to rescind their contract. The club went on to announce as his successor Argyris Pedoulakis ,with the experienced tactician  returning to the western Athens club, where he started his career both as a player and as a coach,  for a fourth stint.

On January 15th,  Peristeri announced they were parting ways with BCL efficiency rating record-holder Steven Gray, who departed for fellow BCL participants Igokea, and that they were signing  Jorge Gutiérrez in his place. The 32-year-old Mexican international started the 2020-21  season at BG Gottingen and averaged 11.7 points and 5 assists per game in the German BBL.

Shortly after reuniting with Pedoulakis, Peristeri signed former FIBA EuroBasket champion and FIBA World Cup silver medalist Ioannis Bourousis. The 37-year-old former Greek international was a free agent after spending last season with Herbalife Gran Canaria, averaging 7.8 points and 4 rebounds per game in the Spanish Liga Endesa.

The next day, the Greek club announced they had also recruited 29-year-old forward Jaye Crockett who started the 2020-21 season at Fribourg Olympic and competed with the Swiss champions in the BCL Qualifiers in September.

Less than 48 hours later, on December 3rd, Peristeri announced they had reached an agreement with their former player Ryan Harrow. The 29-year-old point guard, who had played for the Athens side in 2018-19 under Pedoulakis, started the 2020-21 season at Coosur Real Betis and averaged 8 points and 1.9 assists per game in the Spanish Liga Endesa.

The next addition to the roster after the coaching change was a familiar face in Greek international Evangelos Mantzaris, who started his career at the club and played there until 2011. The 30-year-old guard started the season at Promitheas and averaged 11.3 points and 5.3 assists per game in the Greek Basket League.

In the summer, Peristeri had managed to get their fans excited about the upcoming season by recruiting a host of new players, many of whom with a successful track record at fellow Greek  clubs.

The Athens team brought in Terran Petteway for the starting small forward spot, after the 27-year-old turned heads with his performances in the shortened Italian Serie A season, averaging 16.3 points, 4.3 rebounds and 3 assists per game for Pistoia.

Petteway previously played in the BCL in the 2017-18 season, with fellow Greek side  PAOK and with French side Nanterre. 

Former Virtus Bologna point guard Abdul Gaddy was another summer addition to the yellow-blacks' roster, but Peristeri parted ways with the 28-year-old American on December 16. Gaddy averaged 9.5 points and 6.5 assists in the two BCL games he played with the Athens club.

Peristeri bolstered the frontcourt with two players who coincided briefly at fellow Greek side Promitheas last year, Marvin Jones and veteran Loukas Mavrokefalids, as well as Jonathan Arledge who is coming off a solid season with French BCL newcomers Cholet.

Jones played a couple of games with the Patras club  prior to the Greek Basket League season coming to an abrupt end due to the pandemic, while the club parted ways with Mavrokefalidis following the arrival of Bourousis in December.

Meanwhile Arledge averaged 8.2 points and 4.4 rebounds in the French Jeep Elite up until the league  was canceled.

Peristeri also signed another former Greek international in veteran combo guard Ioannis Athinaiou but parted ways with him upon the arrival of Mantzaris in December.